My blogs

Critical Care Trailblazers: the ACURASYS Trial

Introduction Neuromuscular blockade has been in routine practice in anesthesia and critical care for more than half a century. Claude Bernard, one of the pioneer researchers on neuromuscular blocking agents, conducted groundbreaking animal experiments on the effect of curare in the 19th century. He watched with interest and intrigue as curare administration instantly abolished convulsions arising…

Critical Care Trailblazers: delayed resuscitation in trauma

Bickell WH, Wall MJ, Pepe PE, Martin RR, Ginger VF, Allen MK, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994 Oct 27;331(17):1105–9.  Introduction Early, aggressive fluid administration was long considered to be the key to the resuscitation of patients who suffered major hemorrhage following…

Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension (The CLOVERS trial)

National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network; Shapiro NI, Douglas IS, Brower RG, et al. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med. 2023 Jan 21. doi: 10.1056/NEJMoa2212663. Epub ahead of print. PMID: 36688507.   Background Fluid resuscitation is one…

Critical care trailblazers: the PROSEVA trial – a turn for the better

Introduction More than half a century ago, it was well-known that ventilation of the dependent lung might be impaired in mechanically ventilated patients. Children with cystic fibrosis could expectorate thick, tenacious secretions characteristic of the disease by positioning themselves on their hands and knees. Quite often, such positioning also enabled them to breathe easier (1). Based…

Loading…

Something went wrong. Please refresh the page and/or try again.

Subscribe to My Blog

Get new content delivered directly to your inbox.